Depo-Provera is an injectable contraceptive that contains medroxyprogesterone acetate and is used for contraception in women with a uterus and a history of endometriosis, or endometriosis of the uterus, and other conditions. Depo-Provera is administered every 3-6 months in the absence of a prior abortion and in the presence of a heavy alcohol or fatty alcohol or drug use disorder.
Depo-Provera is a hormonal contraceptive injection. It is a synthetic form of a female hormone called progesterone that is released when the ovaries become receptive to the ovaries' progesterone. The injection contains medroxyprogesterone acetate as the active ingredient and is administered every 3-6 months in the absence of a prior abortion and in the presence of a heavy alcohol or fatty alcohol or drug use disorder.
Depo-Provera is administered in the following ways:
Depo-Provera is available in a wide range of forms and strengths, including:
Depo-Provera can be given in different forms and strengths:
If you are under the age of 18 and do not have a uterus, it is recommended that you use contraceptive foam or gel that contains estrogen-only contraception such as condoms. If you are planning to have a hysterectomy, you may also use a hormonal contraceptive ring that contains a progestin-only contraceptive. You should talk with your healthcare provider to determine the right form of contraceptive for you.
Like all medicines, Depo-Provera may cause side effects. Common side effects include:
If you experience any severe side effects, you should seek immediate medical attention. If you experience a serious side effect, you should contact your healthcare provider immediately.
Other common side effects of Depo-Provera may include:
If you experience any severe side effects, you should contact your healthcare provider immediately.
The injection should not be used if the following conditions may be present:
Depo-Provera is not known to be effective in preventing pregnancy in women who have had a history of endometriosis.
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The Department of Health and Prevention announced a voluntary recall of a single shot used in emergency contraception at the Texas Health Department facility. The drug was linked to a severe skin rash and a decrease in sexual intercourse in men and women, according to the announcement.
The drug was also linked to a decrease in the number of women who used Depo-Provera. A study in 2021 found that women using Depo-Provera had more than twice the amount of drug taken at their last menstrual period. Women also had increased rates of pregnancy and breast cancer, as well as a higher number of prescriptions of Depo-Provera.
Depo-Provera, or medroxyprogesterone acetate, is the first birth control medication to be approved in Texas for preventing pregnancy. In 2018, the FDA approved the use of this hormone to prevent pregnancy. Depo-Provera is used to prevent pregnancy, but it is not as effective as other birth control methods. The FDA also found that women taking Depo-Provera experienced a decrease in pregnancy.
The Depo-Provera recall came after the FDA reported that Depo-Provera was linked to an increased risk of breast cancer. A study found that men and women taking Depo-Provera had more than twice the risk of breast cancer compared with those taking a placebo. The study found that women using Depo-Provera had a 2.7-times higher risk of developing breast cancer than those taking a placebo.
The Department of Health and Prevention is investigating the recall. The agency will continue to monitor the safety of the drugs, but will also be able to adjust the FDA-approved contraceptive to improve safety.
The Texas Department of Public Health says the use of Depo-Provera is not recommended for use during pregnancy. The FDA also found that women using Depo-Provera had increased rates of pregnancy and breast cancer.
The FDA has advised the public that they are being asked to use Depo-Provera as a contraceptive if their health is at risk.
Photo byThis story was republished May 15, 2025 from our journal.
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The Texas Department of Public Health said the use of a contraceptive pill like Depo-Provera could increase the risk of breast cancer and other cancers.
An estimated 1,200,000 Texas women have used Depo-Provera to prevent pregnancy. More than 3,600,000 of those have had a mammogram and over 6,000 had a breast cancer diagnosis in the last year.
“Depo-Provera is a very safe contraceptive,” said Dr. Mark B. Jones, chief medical officer of the Texas Department of Health. “It has been one of the first contraceptive products FDA has approved in Texas since the original manufacturer, Ortho-McNeil, made it available to Texas women, and it has been one of the first birth control methods that has been approved to prevent pregnancy.”
“The FDA is advising that our patients and the public take the responsibility to use the birth control method safely and appropriately,” said Dr. John M. Allen, vice president of the FDA’s Center for Reproductive Health. “The FDA is not going to stop a woman from using Depo-Provera to prevent pregnancy.”
The Texas Department of Public Health says the use of a contraceptive pill like Depo-Provera could increase the risk of breast cancer and other cancers.
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